LarryFrolich.com     


 

 

Variability

 

Wish List

 


 

DNA mutations--the ultimate source of all variation?  Is mutation bad?

 

       

                                              "point" or nucleotide level                                                                                         sequence or chromosome level

 

 

 

Causes of Mutation

 

 

From Thurman et al article in Nature

 

 

Grappling with DNA sequence variation:  The 1000 genomes project and Integrated Map of the Human Genome

 


 

 

Genetic Recombination or Sex

(where DNA, cell-level and individual-level interact in parsing variation)

 

 

Bacteria do it with themselves all the time

 

         

Humans and Bacterias do it also

 

 

 

 

  

Meiosis, Fertilization, LIfe Cycles Sex--a wonder world for producing variability in n and 2n

 

 

 

Crossing Over During Meiosis

Great review article on recombination from Nature

 

 

 

 

Fertilization leads to new individual--Great review of meiosis, fertilization and Punnett Squares from U Penn.

 

 


 

Mendelian discrete traits and inheritance

 

My favorite example---color blindness--make a family tree.

Great review page from Boston University School of Public Health

 

 


 

Population and Quantitative Genetics

 

From discrete genes to a normal distribution--the invention of statistics

Nice review of population genetics from Eastern Washington University

 

Nice review of quantitative traits and their heritability--population genetics--from Washington University

 


 

 

Web Resources

 

Variation page from UC Berkeley Evolution 101 for teachers

 

 

HHMI HOliday Lecture from Charles Sawyers on "From Cancer Genomics to Cancer Drugs"

 

Classic Genetics Simulator

 

STAR--MIT Genetics and other simulators

 

 


Larry M Frolich, Ph.D.     Miami Dade College     Wolfson Campus      Natural Sciences      Miami, FL  33132    Office 1504     (305) 237-7589    e-mail  Creative Commons License