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Variability
Wish List
Mutation--types of mutation,
Causes of mutation
Genetic Recombination or Sex
Mendelian Discrete Traits and Inheritance
Population and Quantitative Genetics
DNA mutations--the ultimate source of all variation? Is mutation bad?
"point" or nucleotide level sequence or chromosome level
Causes of Mutation
Innate level of mutation is necessary--inherent in complexity of system
But some genes, DNA regions, organisms, chromosomes seem to mutate with a higher innate level--why?
Some environmental factors are known mutagens: u-v, x-rays and other radiation, tobacco, viruses (e.g. non-A, non-B hepatitis)
Selection for level of variability
From Thurman et al article in Nature
Grappling with DNA sequence variation: The 1000 genomes project and Integrated Map of the Human Genome
Genetic Recombination or Sex
(where DNA, cell-level and individual-level interact in parsing variation)
Bacteria do it with themselves all the time
Humans and Bacterias do it also
Meiosis, Fertilization, LIfe Cycles Sex--a wonder world for producing variability in n and 2n
Crossing Over During Meiosis
Great review article on recombination from Nature
Fertilization leads to new individual--Great review of meiosis, fertilization and Punnett Squares from U Penn.
Mendelian discrete traits and inheritance
My favorite example---color blindness--make a family tree.
Great review page from Boston University School of Public Health
Population and Quantitative Genetics
From discrete genes to a normal distribution--the invention of statistics
Nice review of population genetics from Eastern Washington University
Web Resources
Variation page from UC Berkeley Evolution 101 for teachers
HHMI HOliday Lecture from Charles Sawyers on "From Cancer Genomics to Cancer Drugs"
STAR--MIT Genetics and other simulators
Larry M Frolich, Ph.D.
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Miami Dade College
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Wolfson
Campus
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Natural Sciences
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Miami, FL
33132
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Office 1504
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(305) 237-7589
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e-mail
